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4-ACO-DMT (4-acetoxy-N,N-dimethyltryptamine) is a synthetic tryptamine molecule which acts as a prodrug for psilocin. In fact, 4-AcO-DMT, or O-acetylpsilocin,  is widely known as “synthetic mushrooms.” 

It was first developed by the inventor of LSD, Albert Hofmann for Sandoz Ltd, the company that patented the drug in 1963.

4-ACO-DMT is commonly used as a tool in scientific research because, like its close relative psilocybin, it can easily cross the blood-brain barrier. When 4-ACO-DMT is ingested, it is broken down into psilocin in the body.

Psilocin is a psychedelic tryptamine compound with similar effects to LSD and psilocybin. 4-ACO-DMT is sometimes sold on the street as "psilacetin", "aco dmt" or "4-aco-det".

4-ACO-DMT has been used in therapeutic settings to treat anxiety, depression and addiction. It is also being studied as a potential treatment for cluster headaches and migraines.

To date, not much data exists on the pharmacology, metabolism, and toxicity of 4-AcO-DMT.

What does 4-ACO-DMT Feel like?

4-ACO-DMT has a similar effect profile to psilocybin mushrooms, with the main difference being that 4-ACO-DMT has a shorter duration of action. The effects of 4-ACO-DMT typically last 4-6 hours, while the effects of psilocybin can last up to 8 hours.

During the peak, you can expect feelings of euphoria, laughter, enhanced creativity,  introspection, feelings of awe and more.

4-ACO-DMT is also generally less intense than psilocybin mushrooms, with users reporting more mild visual distortions and less intense emotional effects.

The Urban Dictionary describes the effects of magic mushrooms versus 4-AcO-DMT this way:

“It's effects differ somewhat from mushrooms. It seems to have a much more relaxing quality to it, which makes it harder to have a bad trip. Several available reports of 4-ACO-DMT compare it favorably to psilocybin, describing it as more euphoric, gentle, warm, and colorful. It has also been described as less jarring/scary, and less likely to produce nausea.”

Erowid have a huge bank of subjective experience reports that are veri detailed and useful to read if you're interested in this substance. 

Check it here:

This is a stand out...

"With the lights off, I became lost in the music. It was as if I were not hearing it anymore. Rather each song became a different room, a different experience I traveled to. Each space was filled with different entities that surrounded me and tended to me. The entities were nurses and specialists working on my soul. Was I was in some kind spiritual hospital being repaired? I could feel them working on my brain telepathically, removing things that needed to be removed, and repairing bad parts that served no positive purpose, replacing those by putting in new, healthy parts."

How to take  4-AcO-DMT

It's typically sold in powder form, and can be taken orally or intranasally.  Oral administration is  the most common choice, but  be warned, it's not the most pleasant tasting. 

As with all psychedelics, it is important to be mindful of set and setting when taking 4-AcO-DMT. Set refers to one's mindset going into the experience, while setting refers to the physical environment. Creating a positive set and setting, free from distractions or anything that could cause anxiety or distress, is crucial for having a positive experience.  

The intensity of the experience will depend on many factors, including the dose, the user's individual physiology and psychology, and the environment in which it is taken. 

4-AcO-DMT Dosage

  • Microdose: 1mg – 5 mg
  • Low Dose: 5 – 10 mg
  • Moderate Dose: 10 – 20 mg
  • High Dose: 20 – 40 mg
  • Heroic Dose: 40 mg +

For a macro dose, oral doses in the 15 to 20 mg range resemble a ~3.5-gram magic mushroom experience.

For a microdose,  1mg – 5 mg is often recommended. Having said that, a cautious approach is recommended.  5mg could produce a noticeable come-up and above perception level effects. 

1 mg would be a good place to start, knowing that you can titrate up or down as required on subsequent occasions.

4-AcO-DMT Trip Duration

A Psilacetin experience can last anywhere between two and eight hours, depending on how much you take (and how you took it). When taken orally, the effects of 4-AcO-DMT are typically felt within 45 minutes, with the peak lasting for two to four hours. 

Does 4-AcO-DMT have a comedown?

Users report a comedown of at least an hour.  

In terms of a longer 'hangover', there are very few reports of anything significant. However, both headaches and trouble sleeping are described on Erowid.

At the same time, there are also lots of reports of an "afterglow" the next day after high-dose experiences.

4-ACO-DMT Side effects

Much like Psilocybin, It’s common to experience sensitivity to light, auditory hallucinations, time distortion, as well as less desirable effects such as over-stimulation, sweating/chills/flushing, aches, dizziness, anxiety and paranoia. However, there is little or no nausea reported like magic mushroom users often experience.

Is 4-AcO-DMT safe?

Of the many lesser studied grey market research chemicals out there, 4-acetoxy-dmt  is (likely) among the safest.

As noted, effects are comparable to those of psilocybin or psilocin, although with important and consistent distinctions. 

Although its toxicity profile is believed to be (nearly) identical with psilocybin mushrooms, which are known to be physiologically non-toxic, there is no hard data to support that claim.

So It is advised to use harm reduction practices if using this substance.

Is 4-AcO-DMT legal?

4-AcO is not included in any international drug schedules like the UN Convention on Psychotropic Substances.

In Canada, there is no legislation for 4-AcO-DMT, and so it’s pretty easy to buy it online.

In the United States, 4-AcO is unscheduled, but you can prosecuted under he Federal Analogue Act  So possession and use of 4-ACO-DMT can result in severe legal penalties (yet in practice, is almost unheard of).

The following countries have banned 4-AcO, Australia, Belgium, Brazil, Germany, Italy, New Zealand, Sweden, United Kingdom and the United States. 


Gwella Mushrooms |
Gwella Mushrooms |


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